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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
13.64
Human Site:
S398
Identified Species:
37.5
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
S398
R
K
G
F
E
L
Q
S
S
L
Y
S
G
I
N
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
P428
K
K
A
F
E
S
E
P
T
L
Q
S
G
I
N
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
P390
R
K
A
F
D
V
E
P
S
L
H
S
G
I
N
Dog
Lupus familis
XP_548885
1422
158482
S494
R
K
G
F
E
L
Q
S
S
L
Y
S
G
I
N
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
S402
R
K
G
F
E
L
Q
S
S
L
Y
S
G
I
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
S484
R
Q
G
F
E
L
Q
S
S
L
Y
S
G
I
N
Chicken
Gallus gallus
XP_419725
1260
143069
W362
L
E
K
L
Q
S
Y
W
E
V
G
S
F
L
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
P414
R
R
G
F
E
S
E
P
T
L
H
S
G
I
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
G368
M
T
L
N
N
L
L
G
K
K
G
S
L
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
53.3
60
100
N.A.
100
N.A.
N.A.
93.3
6.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
73.3
86.6
100
N.A.
100
N.A.
N.A.
100
33.3
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
12
0
0
67
0
34
0
12
0
0
0
0
0
0
% E
% Phe:
0
0
0
78
0
0
0
0
0
0
0
0
12
0
0
% F
% Gly:
0
0
56
0
0
0
0
12
0
0
23
0
78
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
23
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
78
0
% I
% Lys:
12
56
12
0
0
0
0
0
12
12
0
0
0
0
0
% K
% Leu:
12
0
12
12
0
56
12
0
0
78
0
0
12
12
0
% L
% Met:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
12
12
0
0
0
0
0
0
0
0
0
78
% N
% Pro:
0
0
0
0
0
0
0
34
0
0
0
0
0
0
0
% P
% Gln:
0
12
0
0
12
0
45
0
0
0
12
0
0
0
0
% Q
% Arg:
67
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
34
0
45
56
0
0
100
0
0
12
% S
% Thr:
0
12
0
0
0
0
0
0
23
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
12
0
0
0
12
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
12
0
0
0
45
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _